%0 Journal Article
%T Avalia  o do potencial neuroprotetor do ¨®leo essencial de Citrus limon em hipocampo e corpo estriado de camundongos ap¨®s convuls es induzidas pela pilocarpina
%A Lidianne Mayra Lopes CAMP¨ºLO
%A Chistiane Mendes FEITOSA
%A Adriana da Rocha TOM¨¦
%A Rivelilson Mendes de FREITAS
%J Bolet¨ªn Latinoamericano y del Caribe de Plantas Medicinales y Arom¨¢ticas
%D 2011
%I Agriscience University of Santiago de Chile
%X The seizures can produce neuronal damage in several brain structures. The aim of this study was to investigate the potential neuroprotective effect of essential oil of Citrus limon (EOCL) on the histopathological changes observed in the hippocampus and striatum of mice after seizures induced by pilocarpine. Adult Swiss mice were 2 months old. The animals were divided into four groups. The first group was treated with 0.05% Tween 80 (control group) and the second with pilocarpine (400 mg/kg group P400). The third and fourth group were treated with EOCL (150 mg/kg) and 30 min after received P400 (P400 + EOCL group) or 0.05% Tween 80, respectively. After treatment, all groups were observed for 24 h, then sacrificed and their brains removed for histopathological analysis. The group P400, presented with seizures that progressed to status epilepticus in 75% of animals. Pretreatment with OECL produced a 25% reduction in this index. Groups P400 and P400 + EOCL showed 83.33% and 25% of animals with brain damage in the hippocampus, respectively. In the striatum of group P400 was a compromise of 75%. In turn, in the striatal region of group EOCL P400 + was seen a decrease of 58.34% in this neuronal damage. The seizures induced by pilocarpine are installed by the cholinergic system and produce brain damage. According to our results we suggest that the EOCL may modulate epileptogenesis and promote neuroprotective effects during the seizures in the model investigated.
%U http://www.redalyc.org/articulo.oa?id=85617384004