%0 Journal Article
%T Stem-cell treatment in disc degeneration: What is the evidence? C¨¦lulas madre en el tratamiento de degeneraci¨®n de disco:  Cual es la evidencia? C¨¦lulas tronco no tratamento de doen a degenerativa discal: Qual ¨¦ a evid¨ºncia?
%A Manuela Peletti-Figueir¨®
%A Pedro Guarise da Silva
%A Ol¨ªvia Egger de Souza
%A Ana Paula Lambert
%J Coluna/Columna
%D 2013
%I Sociedade Brasileira de Coluna (SBC)
%X To review the potential role of stem cells in treating degenerative disc disease of the intervertebral disc (IVD). A review was performed of articles from the Medline database concerning stem cells and degenerative disc disease (DDD). To discuss the data, the papers were classified as: review, in vitro, experimental, and clinical. The currently available treatments were basically for symptom reduction, not to revert the IVD degenerative process. The use of mesenchymal stem cells (MSC) is being proposed as an option of treatment for DDD. In vitro studies have shown that the MSC are able to differentiate into NP cells and that the MSC also reduce the inflammatory levels of the degenerated IVD. Besides, experimental studies demonstrated that the MSC remained viable when injected into the IVD, and that they were able to regenerate partially from the degenerated IVD and its structure. The few clinical studies found in the literature presented diverging results. The use of MSC is being widely studied and shows promising results for the treatment of DDD. Although many advances are being achieved in studies in vitro and experimental, there is a lack of clinical studies to prove the role of MSC in DDD management. Revisar el papel potencial de las c¨¦lulas madre en el tratamiento de la enfermedad degenerativa del disco intervertebral (IVD). Se realiz¨® una revisi¨®n de los art¨ªculos de la base de datos Medline sobre c¨¦lulas madre y la enfermedad degenerativa del disco (DDD). Para fines de discusi¨®n de los datos, los trabajos se dividieron en: revisi¨®n, in vitro, experimentales y cl¨ªnicos. Los tratamientos disponibles actualmente enfocan b¨¢sicamente la reducci¨®n de los s¨ªntomas, y no la reversi¨®n del proceso degenerativo del IVD. El uso de c¨¦lulas madre mesenquimales (MSC) se propone como una opci¨®n de tratamiento para DDD. Estudios in vitro demostraron que las MSC son capaces de diferenciarse en c¨¦lulas NP y que las MSC tambi¨¦n reducen los niveles inflamatorios de la IVD degenerado. Adem¨¢s, estudios experimentales demostraron que las MSC se mantuvieron viables cuando inyectadas en el IVD y que eran capaces de regenerarse parcialmente del IVD degenerado y su estructura. Los pocos estudios cl¨ªnicos presentes en la literatura presentan resultados divergentes. El uso de MSC se est¨¢ estudiando ampliamente y muestra resultados prometedores en el tratamiento de la DDD. Aunque se hayan logrado muchos avances en estudios in vitro y experimentales, a¨²n faltan estudios cl¨ªnicos para comprobar el papel de las MSC en el manejo de la DDD. Revisar o potencial papel das c¨¦lulas-tron
%K C¨¦lulas Madre
%K Degeneraci¨®n del disco intervertebral
%K Columna vertebral
%K C¨¦lulas madre mesenquimales
%K Disco intervertebral
%K C¨¦lulas-tronco
%K Degenera  o do disco intervertebral
%K Coluna vertebral
%K C¨¦lulas-tronco Mesenquimais
%K Disco intervertebral
%K Stem cells
%K Intervertebral disc degeneration
%K Spine
%K Mesenchymal stem cells
%K Intervertebral disc
%U http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512013000100013