%0 Journal Article
%T Distribution and chemical coding pattern of somatostatin immunoreactivity in the dorsal striatum of the guinea pig
%A Barbara Wasilewska
%A Anna Robak
%A Maciej R¨®wniak
%A Krystyna Bogus-Nowakowska
%J Folia Histochemica et Cytobiologica
%D 2012
%I Polish Histochemical and Cytochemical Society
%R 10.5603/14731
%X The present study provides a detailed description of somatostatin (SOM) distribution and the colocalization pattern of SOM, neuropeptide Y (NPY) and nitric oxide synthase (NOS) in the dorsal striatum (caudate-putamen complex) of the guinea pig. Within the dorsal striatum, SOM is found in a population of medium-sized aspiny interneurons. We found that 97% of all SOM-IR neurons expressed NPY simultaneously, while 98% of all NPY-ergic perikarya was simultaneously SOM-IR. On the other hand, while 98% of all SOM-IR cells were simultaneously NOS-IR, only 91% of all NOS-containing neurons exhibited SOM-immunoreactivity. Irrespective of their chemical coding, both types of SOM-IR neurons were scattered throughout the dorsal striatum, sometimes in the form of small, loosely arranged clusters of 2¨C4 cells. While SOM-IR and NPY-IR nerve fibers were present in all of the studied regions, they were more numerous in the ventro-medial part of the studied structure, with the exception of its caudal portion, where SOM-IR and NPY-IR fibers additionally formed a dense network in the part corresponding to the caudate nucleus. A low expression of staining for NOS-IR fibers was seen throughout the entire dorsal striatum. In some fibers, SOM and NPY were co-expressed. Fibers expressing both SOM and NOS were not found. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 690¨C699)
%K somatostatin
%K nitric oxide synthase
%K neuropeptide Y
%K dorsal striatum
%K guinea pig
%U http://czasopisma.viamedica.pl/fhc/article/view/14731