%0 Journal Article
%T Expression of p130cas, E-cadherin and ¦Â-catenin and their correlation with clinicopathological parameters in non-small cell lung cancer: p130cas over-expression predicts poor prognosis
%A Yuan Miao
%A Ai-Lin Li
%A Liang Wang
%A Chui-Feng Fan
%J Folia Histochemica et Cytobiologica
%D 2012
%I Polish Histochemical and Cytochemical Society
%R 10.5603/11957
%X p130cas (p130 Crk-associated substrate) is a scaffolding protein and plays an important role in regulating focal adhesion and driving cell migration. Also, the destruction of E-cadherin/¦Â-catenin adhesive complex is one of the changes that characterizes the invasive phenotype of tumors. The aim of this study is to evaluate the role of p130cas, E-cadherin, and ¦Â-catenin expression in patients with non-small cell lung cancer (NSCLC). We examined the expression of p130cas, E-cadherin, and ¦Â-catenin in 105 lung cancer tissues and paired adjacent normal lung tissues using immunohistochemistry. The overexpression of p130cas was observed in 61.9% (65/105) of lung cancer samples. The overexpression of p130cas was correlated with abnormal expression of E-cadherin and ¦Â-catenin (P=0.002 and P=0.006, respectively). Chi-square test showed that the overexpression of p130cas correlated positively with lymph node metastasis and high TNM stage. The Log-Rank test revealed that the mean survival time of patients with p130cas overexpression (36.31 ¡À 5.66 months) was markedly shorter than those with p130cas normal expression (60.57 ¡À 6.95 months). Multivariable analysis indicated p130cas overexpression (P<0.001) as an independent significant prognostic factor for NSCLC patients¡¯ survival. These results indicate that p130cas may impact a variety of clinicopathological features of NSCLC and may y influence the prognosis of lung cancer patients.
%K p130cas
%K E-cadherin
%K ¦Â-catenin
%K non-small cell lung cancer (NSCLC)
%K prognosis
%U http://czasopisma.viamedica.pl/fhc/article/view/11957