%0 Journal Article
%T The expression of B7-H1 and B7-H4 molecules on immature myeloid and lymphoid dendritic cells in cord blood of healthy neonates
%A Kludka-Sternik M
%A Serafin A
%A Darmochwal-Kolarz D
%A Radej S
%J Folia Histochemica et Cytobiologica
%D 2010
%I Polish Histochemical and Cytochemical Society
%X The aim of our study was to estimate both B7-H1 and B7-H4 molecules on immature myeloid and lymphoid dendriticcells in umbilical cord blood of healthy neonates in comparison with peripheral blood of healthy adults. Thirty ninehealthy full-term neonates from physiological single pregnancies and 27 healthy adults were included in the study. Theexpression of B7-H1 and B7-H4 was revealed using the immunofluorescence method. Statistical analysis was performedusing a non-parametric test (Mann-Whitney U-Test). The percentages of BDCA-1+ dendritic cells with B7-H1 and B7-H4expressions were significantly higher in peripheral blood of healthy adults (p<0.00003). It was either observed that the percentageof BDCA-2+ dendritic cells with the expression of B7-H4 molecules was significantly higher in peripheral blood ofhealthy adults in comparison with umbilical cord blood (p<0.02). Decreased percentages of dendritic cells and co-stimulatorymolecules indicate that neonates have immature immune system. Depletion of co-stimulatory B7-H1 and B7-H4 moleculesenable appropriate development of immune response.
%K B7-H1
%K B7-H4
%K BDCA-1+
%K BDCA-2+
%K cord blood
%K neonates.
%U http://www.fhc.viamedica.pl/darmowy_pdf.phtml?indeks=128&indeks_art=1299