%0 Journal Article
%T Pharmacokinetics, urinary excretion and plasma protein binding of ofloxacin in water buffalo calves (Bubalus bubalis)
%A Ajay K. Ola
%A Harpal S. Sandhu
%A Vinod K. Dumka
%A Bibhuti Ranjan
%J Journal of the South African Veterinary Association
%D 2013
%I AOSIS OpenJournals
%R dx.doi.org/10.4102/ jsava.v84i1.130
%X Pharmacokinetics and urinary excretion of an intravenous dose of 5 mg.kg每1 ofloxacin were investigated in water buffalo calves. Plasma concentrations of ofloxacin were determined by high-performance liquid chromatography. Ofloxacin was rapidly distributed from the central to the peripheral compartment as evidenced by a short distribution half-life (0.09 h ㊣ 0.003 h) and high K12 (4.7 h每1 ㊣ 0.1 h每1), and was detected in plasma for 8 h. The large volume of distribution (2.48 L.kg每1 ㊣ 0.18 L.kg每1) obtained in this study indicated high distribution of ofloxacin in water buffalo calves. The elimination half-life, the area under the plasma drug concentration每time curve and total body clearance were 2.11 h ㊣ 0.13 h, 6.20 米g.mL〞1 ㊣ 0.23 米g.mL〞1.h and 0.81 mL.kg每1.h每1 ㊣ 0.03 mL.kg每1.h每1, respectively. About 18.7% of administered drug was bound to plasma proteins and approximately 32.5% of the administered dose was recovered in urine within 48 h. The results of the study indicated a favourable pharmacokinetic profile of ofloxacin in water buffalo calves, which suggests that ofloxacin may be effective against urinary pathogens in this species.
%K ofloxacin
%K pharmacokinetics
%K protein binding
%K urinary excretion
%U http://www.jsava.co.za/index.php/jsava/article/view/130/1095