%0 Journal Article
%T A novel route to 3-hydroxy-16,17-seco-estrone derivatives (NOTE)
%A SUZANA S. JOVANOVIC-SANTA
%A VJERA M. PEJANOVIC
%A JULIJANA A. PETROVIC
%J Journal of the Serbian Chemical Society
%D 1999
%I Serbian Chemical Society
%X Starting from 3-benzyloxy-17-hydroxy-16,17-secoestra-1,3,5(10)-triene-16-nitrile (1b), 17-tosylate 2b and also 17-chloro-, 17-bromo- and 17-iodo-derivatives 4b, 5b, and 6b, were obtained. The fluoro-derivative 3b was obtained from 2b in the reaction with tetrabutyl ammonium fluoride. The deprotection of the 3-hydroxyl group was achieved by action of hydrogen in presence of Pd/C as a catalyst, yielding six new 3-hydroxy-16,17-seco-estrone derivatives.
%K 3-hydroxy-16
%K 17-seco-estrone derivatives
%K halogeno steroids
%K hydrogenolysis
%U http://www.shd.org.yu/HtDocs/SHD/Vol64/No5-Pdf/V64-no5&6-9.zip