%0 Journal Article
%T The synthesis of a small library of prospective growth hormone secretagogues
%A VOJISLAV PEJOVIC
%A VUKIC SOSKIC
%A JELENA JOKSIMOVIC
%J Journal of the Serbian Chemical Society
%D 1999
%I Serbian Chemical Society
%X Employing tools of combinatorial chemistry, an original methodological approach has been developed and applied for the design and synthesis of a small library of peptide-like compounds, prospective growth hormone (GH) secretagogues. For this purpose seven building blocks of tBoc- and Fmoc-protected amino acids was used. In this way, a small, tripeptoid library on polyethylene glycol monomethyl ether 5000 (PEG 5000) as a soluble support was obtained. The library was screened by a new, simple system, based on polyclonal rabbit antiserum raised against "GH secretagogue pharmacophore" of a known growth hormone secretagogue GHRP-6 (Hexarelin ) and the most promising GH secretagogue candidate was selected.
%K secretagogue
%K growth hormone
%K combinatorial chemistry
%U http://www.shd.org.yu/HtDocs/SHD/Vol64/No10-Pdf/V64-no10-02.zip