%0 Journal Article
%T 7,8,15,16-tetraoxa-dispiro[5.2.5.2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity
%A IGOR OPSENICA
%A NATASA TERZIC
%A DEJAN OPSENICA
%A WILBUR K. MILHOUS
%J Journal of the Serbian Chemical Society
%D 2004
%I Serbian Chemical Society
%X Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro[5.2.5.2] hexadecane-3-carboxamide being as active as artemisinin.
%K mixed tetraoxane
%K malaria
%K Plasmodium falciparum
%K gem-dihydroperoxide
%U http://www.shd.org.yu/HtDocs/SHD/Vol69/No11/V69-No11-11.pdf