%0 Journal Article
%T Synthesis and reactions of 4-(p-methoxybenzyl)-6-[5,6,7,8-tetrahydro-2-naphthyl]-pyridazin-3(2H)-one
%A NAGWA M.S. EL-DIN HARB
%J Journal of the Serbian Chemical Society
%D 1999
%I Serbian Chemical Society
%X The condensation of 4-(p-methoxybenzyl)-6-[5,6,7,8-tetrahydro-2-naphthyl]-pyridazin-3(2H)-one (3), prepared by the reaction of 6-[5,6,7,8-tetrahydro-2-naphthyl]-4,5-dihydropyridazin-3(2H)-one (1) and anisaldehyde, with dimethyl sulphate, formaldehyde and acrylonitrile, and also the formation of the Mannich base, proceeded smoothly at the 2-position to give compounds 4,5,6,7, respectively. 4-p-Methoxybenzyl-3-chloro-6-[5,6,7,8-tetrahydro-2-naphthyl]-pyridazine (9) was prepared in law yield by the action of phosphorus oxychloride on 3. The reaction of 9 with benzylamine, aniline and piperidine gave 10a,b,c, respectively. 4-p-Methoxybenzyl-6-[5,6,7,8-tetrahydro-2-napthyl]pyridazine-3(2H)-thione (12) was prepared either by the action of thiourea on 9, or by the reaction of 3 with phosphorus pentasulphide. The reaction of these thiones with acrylonitrile, morpholine and piperidine to give 13 and 14 a,b, respectively, were also investigated.
%K pyridazin-3(2H)-one
%K dimethyl sulphate
%K formaldehyde
%K acrylonitrile
%K chloropyridazine
%K benzylamine
%K aniline
%K piperidine
%K pyridazinthione
%K morpholine
%U http://www.shd.org.yu/HtDocs/SHD/Vol64/No11-Pdf/V64-no11-03.zip