%0 Journal Article
%T Synthesis of new 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one derivatives
%A S. SUKDOLAK
%A N. VUKOVIC
%A S. SOLUJIC
%A M. MILOSEV
%J Journal of the Serbian Chemical Society
%D 2006
%I Serbian Chemical Society
%X Aminothiazole derivatives of 4-hydroxy-2H-chromen-2-one were prepared by the Hantzsch reaction1 using 3-(2-bromoacetyl)-4-hydroxy-2H-chromen-2-one and thiourea derivatives. Starting compound for this synthesis 3-(2-bromoacetyl)-4-hydroxy- 2H-chromen-2-one (1) was prepared previously.2 Also, for this synthesis we used thiourea derivatives (2a¨Cj) as compounds which possess groups with biological activity. Reactions are carried out in refluxing ethanol for a period of 30 ¨C 45 min. Final products (3a¨Cj) are obtained in a high yield. Chemical structure of the obtained compounds was confirmed by elemental and structural analysis (IR and 1H NMR spectroscopy).
%K Hantzsch reaction
%K 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one derivatives
%U http://www.shd.org.yu/HtDocs/SHD/Vol71/No5/JSCS_V71_No6-02.pdf