%0 Journal Article
%T Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin
%A SLOBODANKA JOVANOVIC
%A MILANKA VICO-STEVANOVIC
%A DRAGANA UGLJESIC-KILIBARDA
%A DRAGICA POPADIC
%J Journal of the Serbian Chemical Society
%D 2006
%I Serbian Chemical Society
%X Two new and improved procedures were developed for the synthesis of 1-(1-naphthyloxy)-2,3-epoxypropane as an important intermediate in the production of the beta-blocker and antioxidant, 1-[(1-methylethyl)amino]-3-(1-naphthyloxy)-2-propanol (propranolol). Both base homogeneous and heterogeneous PTC catalysis were employed. High yields and remarkable selectivity were achieved. The improved purity is particularly important, in view of the quality requirements for propranolol hydrochloride as an active pharmaceutical ingredient.
%K heterogeneous PTC catalysis
%K base homogeneous catalysis
%K selectivity
%K yield
%K model system
%U http://www.shd.org.yu/HtDocs/SHD/Vol71/No8-9/JSCS_V71_No8-9-03.pdf