%0 Journal Article
%T The effect of copper intrauterine devices on the expression of mucin 1 and integrin ¦Â1 in the luteal phase endometrium
%A Eray £¿al£¿£¿kan
%A Yi£¿it £¿ak£¿ro£¿lu
%A Ebru Co£¿kun
%A Banu Kumbak
%J Journal of the Turkish-German Gynecological Association
%D 2009
%I Aves Yayincilik
%X Objective: To evaluate the effect of a copper intrauterine device on the expression of mucin- 1 (MUC1) and  ntegrin ¦Â1 in the luteal phase endometrium.Material and Methods: 25 regularly menstruating women (25-35 years) who were willing to use copper intrauterine device contraception participated in this study. Endometrial sampling via a Pipelle canulla was performed on the 24th day of their cycle and repeated three months after insertion of TCu380A IUD. Immunohistochemical staining was performed for MUC1 and integrin ¦Â1 in the endometrial sections. Staining intensity was graded under the conventional light microscope. Results: The mean age of the study population was 32.8¡À5.3 years (25-35). MUC1 expression of the endometrial luminal epithelium cytoplasm and the luminal epithelium increased significantly after three months of IUD usage (p=0.01; p<0.001 respectively). Neither integrin ¦Â1 expression of endometrial luminal epithelium cytoplasma nor of the endometrial stroma changed after three months of IUD usage (p=0.16; p=0.22 respectively). Conclusion: The increase of the embryo implantation inhibitor MUC1 synthesis may be responsible for the IUD¡¯s mechanism of action for pregnancy prevention. Integrin ¦Â1 expression of the endometrial luminal epithelium cytoplasm and stroma are not affected by the use of copper IUD.
%K MUC-1
%K Integrin ¦Â
%K 1
%K intrauterine device
%K TCu380A
%K luteal phase endometrium
%U http://www.journalagent.com/z4/download_fulltext.asp?pdir=jtgga&plng=tur&un=JTGGA-93723