%0 Journal Article
%T A novel osteogenesis technique: The expansible guided bone regeneration
%A Osama Zakaria
%A Marwa Madi
%A Shohei Kasugai
%J Journal of Tissue Engineering
%D 2012
%I 
%R 10.1177/2041731412441194
%X Guided bone regeneration is a unique osteogenesis technique that requires a barrier membrane under periosteum to create space for bone regeneration. However, creating sizeable spaces is clinically not commonly feasible. A titanium plate and a thin silicone membrane were surgically layered on each calvaria of eight rabbits. Then, the periphery of the silicone membrane was fixed by a plastic ring to the underlying bone using titanium micro screws. After 1 week, a 5-mm-length titanium screw was used to elevate the titanium plate, which in turn elevated the silicone membrane together with overlying soft tissue in a rate of 1 mm/day for 5 days to create a secluded space. Animals were killed at 2 months (n = 4, group 1) and 4 months (n = 4, group 2) after the elevation. Histological and microradiographical analyses demonstrated creation of an amount of de novo bone formation (68.2 ˇŔ 22 mm3 in group 1 and 70.3 ˇŔ 14 mm3 in group 2) in the sizeable created spaces (207.1 ˇŔ 31 mm3 in group 1 and 202 ˇŔ 21 mm3 in group 2) without exposure of the device. This novel osteogenesis technique, ˇ°expansible guided bone regeneration,ˇ± created a substantial in vivo incubator without applying growth factors or osteoprogenitor cells. Creating a growing space over the secluded surface allowed the development of normal biological healing process occurring on the bone surface into a regenerative process, generating bone outside the genetically determined skeletal bone. This technique is a new tissue engineering approach stimulating endogenous tissue repair without applying cells or factors exogenously.
%K tissue engineering
%K facilitated endogenous repair
%K in vivo bone incubator
%K in situ bone incubator
%K expansible guided bone regeneration
%K supraosteal bone neogenesis
%K de novo bone
%K bone induction
%U http://tej.sagepub.com/lookup/doi/10.1177/2041731412441194