%0 Journal Article
%T Effectiveness of different immunomodulator agents in the treatment of experimentally induced endometriosis
%A Ne£¿e G¨¹l Hilali
%A Aykut Barut
%A Ilker Ar£¿kan
%A Mehmet Harma
%J Journal of the Turkish-German Gynecological Association
%D 2009
%I Aves Yayincilik
%X Objective: : We aimed to investigate the effects of levamisole, interferon alpha-2b and leuprolide on peritoneal implants in experimentally induced peritoneal endometriosis in rats.Material and Methods: Peritoneal endometriosis was induced in 48 rats by Vernon and Wilson¡¯s method. Four weeks after this procedure, peritoneal implants were evaluated histopathologically, and rats were randomized to four groups treated respectively with: a) a single 1 mL intraperitoneal dose of 0.9% saline solution (control group); b) a single 1 mg intramuscular dose of leuprolide acetate; c) interferon alpha-2b, 100.000 U intraperitoneally; d) levamisole 2 mg intraperitoneally for 3 days, then 3 days rest, and continuing in this fashion over 6 weeks. Rats were sacrificed six weeks after the initiation of treatment, and endometriotic implants were evaluated macroscopically and histopathologically. Microscopic evaluations were scored as (+), (++), (+++) corresponding respectively to normal, mild or severe atrophy of the glands and stromas. Results were evaluated with chi-square test by SPSS 10.0 package program. A value of p <0.05 was considered significant.Results: Comparing treatment groups with the control group, leuprolide (p <0.05) and interferon alpha-2b (p <0.05) were effective, but levamisole was ineffective (p >0.05).Conclusions: There is substantial evidence that immunologic factors play a role in the pathogenesis of endometriosis, and it could be expected that immunomodulator agents would be useful in its treatment. In this group of agents, interferon alpha-2b was effective, but levamisole was ineffective. Further studies will certainly bring more insight into this disease and will determine the effectiveness of different immunomodulator agents in its treatment.
%K Experimental endometriosis
%K treatment
%K levamisole
%K interferon
%K leuprolide
%U http://www.journalagent.com/z4/download_fulltext.asp?pdir=jtgga&plng=tur&un=JTGGA-65982