%0 Journal Article %T Novel isoquinoline derivatives from isochromen-1,3-dione %A Mahmoud Refaee Mahmoud %A Manal Mohamed El-Shahawi %A Eman Abd El-Fattah El-Bordany %A Fatma Saber Mohamed Abu El-Azm %J European Journal of Chemistry %D 2010 %I %R 10.5155/eurjchem.1.2.134-139.71 %X A number of novel isoquinoline derivatives have been synthesized using the readily obtainable (E)-4-(3,4-dimethoxybenzylidene)-4H-isochromene-1,3-dione, 2, via the reaction with different nitrogen nucleophiles such as cyanoethanoic hydrazide, cyclohexylamine, 2-aminothiophenol and p-toluenesulfonohydrazide. Furthermore, the reactivity of 2 towards thiophenol, and ethylcyanoacetate has been investigated. %K Isochromene-1 %K 3-dione %K Isoquinolines %K 2-Cyanoethanoic hydrazide %K Nitrogen nucleophiles %U http://www.eurjchem.com/index.php/eurjchem/article/view/71