%0 Journal Article
%T Facile synthesis of 3-(1-(4'-(3-chloro-2-(substituted phenyl)-4-oxoazetidin-1-yl)biphenyl-4-yl)-5-oxo-2-phenyl-1H-imidazol-4(5H)-ylidene)indolin-2-ones: ¦Â-Lactam derivatives as antimicrobes
%A Abha Bishnoi
%A Krishna Srivastava
%A Suruchi Singh
%A Chandrakant Mani Tripathi
%J European Journal of Chemistry
%D 2011
%I 
%R 10.5155/eurjchem.2.3.359-364.439
%X A facile synthesis of b-lactam derivatives; 3-(1-(4'-(3-chloro-2-(substituted phenyl)-4-oxoazetidin-1-yl)biphenyl-4-yl)-5-oxo-2-phenyl-1H-imidazol-4(5H)-ylidene)indolin-2-ones (6a-e) and 3-(1-(3-chloro-2-(substituted phenyl)-4-oxoazetidin-1-yl)-5-oxo-2-phenyl-1H-imidazol-4(5H)-ylidene)indolin-2-ones (7a-e) is described herein. The title compounds 6a-e and 7a-e were evaluated for their in vitro antimicrobial activity against Candida albicans and Bacillus subtilis respectively using a two fold serial dilution technique. Investigation revealed that 2-hydroxy phenyl function at b-lactam ring in compounds 6d and 7d is a key factor for both antifungal and antibacterial activity, as newly designed compounds 6d and 7d exhibited good biological activity with minimum inhibitory concentration (MIC)12.5 mg/mL against Candida albicans and Bacillus subtilis respectively.
%K Imidazole
%K Azetidinones
%K ¦Â-lactam ring
%K Bacillus subtilis
%K Candida albicans
%K Antimicrobial activity
%U http://www.eurjchem.com/index.php/eurjchem/article/view/439