%0 Journal Article
%T Synthesis and studying the antitumor activity of novel 5-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thiones
%A Shadia Ahmed Galal
%A Ahmed S. Abdelsamie
%A Mireya L. Rodriguez
%A Sean M. Kerwin
%J European Journal of Chemistry
%D 2010
%I 
%R 10.5155/eurjchem.1.2.67-72.1
%X The influence of the incorporation of 1,3,4-oxadiazole ring into 2-methyl-1H-benzimidazole derivatives producing a series of substituted 5(6)-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazoles on the antitumor activity was studied in this study. The antitumor activity of the new compounds was tested against breast cancer cell line MCF-7 and lung cancer cell line A549. S-5-(2-methyl-1H-benzo[d]imidazol-5-yl)-1,3,4-oxadiazol-2-yl 2-nitrobenzenesulfonothioate (9) showed potent activity against both MCF-7 and A549 cell lines. Whereas, compounds 7, 11-13 and 15-17 have moderate growth inhibitory activity on the two cell lines.
%K Salicylate
%K Hydrogen bonding
%K DFT-Molecular dynamics
%K Vibrational spectroscopy
%K Relaxation spectroscopy
%U http://www.eurjchem.com/index.php/eurjchem/article/view/1