%0 Journal Article
%T Synthesis and bioactivity of phosphorylated derivatives of stavudine
%A Alahari Janardhan Rao
%A Valasani Koteswara Rao
%A Pasupuleti Visweswara Rao
%A Chamarthi Naga Raju
%J European Journal of Chemistry
%D 2010
%I 
%R 10.5155/eurjchem.1.4.297-301.20
%X Novel phosphorylated derivatives of stavudine were synthesized by the reaction of bis(2-chloroethyl)phosphoramidic dichloride/4-nitrophenyl phosphorodichloridate with various cyclic amines and amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the corresponding monochloride intermediates 2a-l. Further reaction of the intermediates 2a-l with stavudine in tetrahydrofuran and pyridine in the presence of triethylamine formed the title compounds 4a-l. Their structures were characterized by IR,   1H-, 13C-, 31P-NMR and mass spectral data analyses. They exhibited good antibacterial and antioxidant activities. Their bioactivity was greatly influenced by the different groups present at the phosphorus.
%K Phosphorylated derivatives of stavudine
%K Gram-positive bacteria
%K Gram-negative bacteria
%K Antibacterial activity
%K Antioxidant activity
%U http://www.eurjchem.com/index.php/eurjchem/article/view/20