%0 Journal Article
%T Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative
%A Pe£¿anha Emerson P.
%A Fraga Carlos A. M.
%A Barreiro Eliezer J.
%A Braga Maria F. M.
%J Journal of the Brazilian Chemical Society
%D 2001
%I Sociedade Brasileira de Qu¨ªmica, SBQ
%X As part of a research program aiming at the design, synthesis and pharmacological evaluation of a novel lead-candidates of neuroactive compounds, we describe herein the synthesis and the central profile of a new nebracetam analog having a 2-aza-bicyclo[3.3.0]octane system. The new derivative, designed on the basis of the conformational restriction concept, was synthesized in good yields exploring a diastereoselective reductive-amination and cyclization one-pot sequence. The pharmacological profile of this new compound, investigated by using path-clamp techniques on neurons of the CNS, indicated no effects on these cells.
%K 2-azabicyclo[3.3.0]octane derivatives
%K diastereoselective reductive-amination/cyclization one-pot process
%K nebracetam analog
%U http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300013