%0 Journal Article
%T SYNTHESIS AND CYTOTOXIC ACTIVITY OF GERANYLMETHOXYHYDROQUINONE DERIVATIVES
%A Evelyn Baeza Maturana
%A Karen Catal¨¢n Mar¨ªn
%A Joan Villena Garc¨ªa
%A H¨¦ctor Carrasco Altamirano
%J Journal of the Chilean Chemical Society
%D 2012
%I Sociedad Chilena de Qu¨ªmica
%X The new synthetic geranyl-2,4-methoxyhydroquinone 1 and the known geranyl-4,5-methoxyhydroquinone 2 were prepared by Electrophilic Aromatic Substitution (EAS) reactions between geraniol and 1,3,5-trimethoxyphenol using BF3¡¤Et2O as a catalyst. Furthermore, the new geranylmethoxyhydroquinones derivatives (3-6) were obtained by chemical transformations of 1 and 2. The compounds have been evaluated for their cytotoxic activities against PC-3 human prostate cancer cell line, MCF-7 and MDA-MB-231 human breast cancer cells lines and dermal human fibroblasts DHF. IC50 values for compounds 1 and 5 ranged in the 80 ¦ÌM level.
%K Geranylmethoxyhydroquinone
%K synthesis
%K cytotoxic activity
%U http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300005