%0 Journal Article
%T ONE-POT SYNTHESIS OF POLYSUBSTITUTED IMIDAZOLES FROM ARYLALDEHYDES IN WATER CATALYZED BY NHC USING MICROWAVE IRRADIATION
%A Lei Wu
%A Xiaobi Jing
%A Hongxiang Zhu
%A Yinlil Liu
%J Journal of the Chilean Chemical Society
%D 2012
%I Sociedad Chilena de Qu¨Şmica
%X A simple, high yielding synthesis of tri (3a-i) and tetrasubstituted (4a-g) imidazols from aldehydes is described. The cornerstone of this methodology involves the condensation of NH4OAc, substituted aldehydes, and benzoin, which is synthesized in situ from aldehydes catalyzed by N-heterocyclic carbine (NHC), under microwave irradiation in water to afford trisubstituted imidazoles (3a-i). If arylamine is added in the solution, tetrasubstituted imidazoles (4a-g) can be obtained. Lepidilines B and trifenagrel are also synthesized in high yield using this procedure. All the experiment deta are in agreement with the literature.
%K Trisubstituted imidazoles
%K tetrasubstituted imidazoles
%K microwave irradiation
%K Lepidilines B
%K Trifenagrel
%K N-heterocyclic carbine (NHC)
%U http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300002