%0 Journal Article %T Statistical modeling for differential transcriptome analysis using RNA-Seq technology %A Jeffrey Charles Miecznikowski %A Song Liu %A Xing Ren %J Journal of Solid Tumors %D 2012 %I %R 10.5430/jst.v2n5p33 %X RNA-Seq is a recently developed technology for transcriptome profiling. Numerous advantages of RNA-Seq suggest that it will be the platform of choice for genome-wide expression studies. RNA-Seq generates large volumes of data which require statistical methods for data processing and accurate inference. This article reviews the RNA-Seq technologies followed by a detailed discussion of current statistical methods for normalization and differential expression analysis. %U http://www.sciedu.ca/journal/index.php/jst/article/view/1305