%0 Journal Article
%T Synthesis of 8-hydroxy-6-methoxy-3-pentyl-1H-isochromen-1-one from Tessmannia densiflora
%A Aamer Saeed
%J European Journal of Chemistry
%D 2011
%I 
%R 10.5155/eurjchem.2.1.117-119.201
%X The synthesis of 8-hydroxy-6-methoxy-3-pentyl-1H-isochromen-1-one (1) isolated from the stem and root bark extracts of Tessmannia densiflora has been described. The reaction of 3,5-dimethoxyhomophthalic anhydride (2) with hexanoyl chloride in the presence of 1,1,3,3-tetramethylguanidine and triethylamine afforded 6,8-dimethoxy-3-pentylisocoumarin (3). Regioselective demethylation of the latter using anhydrous aluminum chloride furnished the title isocoumarin (1).
%K Isocoumarin
%K Tessmannia densiflora
%K 3
%K 5-Dimethoxyhomophthalic acid
%K Antimalarial
%K 3
%K 5-Dimethoxyhomophthalic anhydride
%K Mechanism
%U http://www.eurjchem.com/index.php/eurjchem/article/view/201