%0 Journal Article
%T Synthesis and reactions of (Z)-2-imino-5-(3,4,5-trimethoxy benzylidene)thiazolidin-4(H)one
%A Mahmoud Refaee Mahmoud
%A Hassan Mohamed Fawzy Madkour
%A Eman Abd El-Fattah El-Bordany
%A El-Sayed Ahmed Soliman
%J European Journal of Chemistry
%D 2011
%I 
%R 10.5155/eurjchem.2.4.475-479.193
%X 5-Arylmethylene-2-imino-4-oxo-2-thiazolidine 3 was obtained as the sole product from the reaction of ¦Á-cyano-3,4,5-trimethoxy cinnamonitrile and/or ethyl-¦Á-cyano-3,4,5-trimethoxy cinnamate (1a,b) with 2-imino-4-oxo-2-thiazolidine 2. The reaction of 3 with benzyl amine gave the imidazolidin-4(H)one derivative 4 while with hydrazine hydrate afforded the dimeric product 5. Also, reaction of thiazolidinone derivative 3 with piperidine gave thiazol-4(5H)one derivative 6 which on treatment with Grignard reagent and active methylene compounds afforded thiazolidin-4-one derivatives 7-9, respectively. Compound 6 was converted to the potassium salt 10 which treated with acetic acid, ethyl chloroacetate and furoyl chloride to give the compounds 11-13, respectively. The structures of all new compounds were evidenced by microanalytical data and spectral data.
%K Iminothiazolidinone derivatives
%K Grignard reagents
%K Imidazolidinone derivative
%K 2-Thiazolidin-4-one
%K Nitrogen nucleophiles
%K Activated nitriles
%U http://www.eurjchem.com/index.php/eurjchem/article/view/193