%0 Journal Article
%T Synthesis and characterization of a novel series of benzenesulfonylurea and thiourea derivatives of 2H-pyran and 2H-pyridine-2-ones as antibacterial, antimycobacterial and antifungal agents
%A Hassan Mostafa Faidallah
%A Khalid Ali Khan
%A Abdullah Mohammad Asiri
%J European Journal of Chemistry
%D 2011
%I 
%R 10.5155/eurjchem.2.2.243-250.257
%X Arylhydrazines reacted with dehydroacetic acid (1) to give the corresponding 2H-pyran-2-one hydrazones (2), which on treatment with hydrazine hydrate afforded the corresponding 1-amino-2H-pyridin-2-ones (3). Reaction of 3 with nitrous acid, aromatic aldehyde and substituted benzenesulfonyl chlorides yielded the corresponding 2H-pyridine-2-one derivatives. A series of urea and thiourea derivatives were also prepared. Some of these compounds have shown significant antibacterial and mild to moderate antimycobacterial and antifungal activities.
%K 2H-pyran-2-one hydrazones
%K 1-Amino-2H-pyridin-2-ones
%K Benzenesulfonylurea derivatives
%K Thiourea derivatives
%K Antimicrobial activity
%K Antimycobacterial activity
%U http://www.eurjchem.com/index.php/eurjchem/article/view/257