%0 Journal Article
%T Development of Floating Drug Delivery System with Biphasic Release for Verapamil Hydrochloride: In vitro and In Vivo Evaluation.
%A Londhe S
%A Gattani S
%A Surana S
%J Journal of Pharmaceutical Science and Technology
%D 2010
%I 
%X The purpose of the research work was development and evaluation bi-layer floating tablets for verapamil hydrochloride. Verapamil hydrochloride has pH dependent solubility. It has coronary vasodilator, antihypertensive category therefore necessary to facilitate immediate onset of action followed by prolong duration of action of drug. Verapamil hydrochloride bi-layer floating tabletshave two layers one immediate release layer and second floating sustained release layer. Verapamil hydrochloride bi-layer floating tablet releases drug in two phases i.e immediate and sustained drugrelease. Direct compression method was used to formulate bi-layer floating tablets. All bi-layer formulation float more than 12 h and sustained drug release above 12 h. Kinetic release study suggests that release mechanism is quasi Fickian. The optimized formulation was selected based on in vitro characteristics and used in vivo radiographic studies in rabbits by incorporating BaSO4. This showed that, tablet significantly float in rabbit stomach for more than 7 h.
%K Verapamil Hydrochloride
%K Bi-layer floating tablets
%K Biphasic release
%K Release kinetics
%K In vivo study.
%U http://www.onlinepharmacytech.info/docs/vol2issue11/JPST10-02-11-02.pdf