%0 Journal Article
%T A Novel Quantitative Spectrophotometric Method for the Analysis of Gabapentin Hydrochloride
%A Rajinder Singh Gujral
%A Sk Manirul Haque
%A Prem Shanker
%J Journal of Pharmaceutical Science and Technology
%D 2010
%I 
%X A simple Spectrophotometric method is developed for the determination of gabapentin hydrochloride because at present there is no official method for the analysis of gabapentin hydrochloride. The method is based on the reaction of carboxylic acid group of gabapentinhydrochloride with a mixture of potassium iodate (KIO3) and iodide (KI) to form yellow colored product in aqueous medium at 25 ¡À 1o C. The reaction is followed spectrophotometrically by measuring absorbance at 450 nm. Under optimized experimental conditions, Beer¡¯s law is obeyed in the concentration range of 21.2 ¨C 159.0 ¦Ìg/mL. The method is validated with respect to accuracy, precision, limit of detection and limit of quantitation. Robustness testing is alsoconducted to evaluate the effect of minor changes to the absorbance of the product.
%K Spectrophotometer
%K Gabapentin Hydrochloride
%K Potassium Iodate
%K Potassium Iodide
%K Validation.
%U http://www.onlinepharmacytech.info/docs/vol2issue5/JPST10-02-05-02.pdf