%0 Journal Article %T Pulmonary Alveolar Proteinosis in Children: A case series %A seyyed Ahmad Tabatabaei %A abdollah karimi %A Sedigheh Rafiee Tabatabaei %A B Radpay %J Journal of Research in Medical Sciences %D 2010 %I Isfahan University of Medical Sciences %X Pulmonary Alveolar Proteinosis(PAP) is a rare disease of unknown etiology, characterized by the accumulation of proteinoceous material in the alveoli that is rich in lipid and is positive on periodic acid-Schiff(PAS) stain. PAP is rare in children. Two forms are encountered in pediatric practice: congenital alveolar proteinosis (CAP) and a later¨Conset form that is generally less severe. Broncho-alveolar lavage is the key to diagnosis. Therapeutic lung lavages are the only effective treatment for severe cases. Other therapeutic trials have been proposed such as: lung transplantation, adminstration of GM- CSF and gene-therapy. This case series presents six cases of PAP which were diagnosed by open lung biopsy in Mofid children hospital in Tehran capital city over a three-year period (2003¨C2006) and one in 1998. The aim of the present study was to provide detailed data on the characteristics of these patients and the methods of diagnosis and treatment. %K Pulmonary Alveolar Proteinosis %K Children %U http://journals.mui.ac.ir/jrms/article/view/2744