%0 Journal Article
%T Epilepsy and its Management: A Review *1,2, 1 1 2
%A Hirak Kumar Mukhopadhyay*1
%A 2
%A Chandi Charan Kandar1
%A Sanjay Kumar Das1
%A Lakshmikanta Ghosh2
%J Journal of PharmaSciTech
%D 2012
%I Trinity Trust
%X Now-a-days, people are facing various kind of stress in the fast daily life and most of the people in the world are suffering from various neurological disorder. Epilepsy is one of the most common neurologic disorders of the brain, affecting about 50 million individuals worldwide and 90% of them are from developing countries. Genetic factors as well as infection in brain, stroke, tumor and high fever cause epilepsy. It imposes a large economic burden on health care systems of countries associated with stigma and discrimination against the patient and even his/her family in the community, workplace, and school and home. Many patients with epilepsy suffer severe emotional distress, behavioural disorders and extreme social isolation. There are many seizure types and different mechanisms by which the brain generates seizures. The two hallmarks of seizure generation are hyperexcitability of neurons and hypersynchrony of neural circuits. A large variety of mechanisms alters the balance between excitation and inhibition to predispose a local or widespread region of the brain to hyperexcitability and hypersynchrony. The objective of the review is to discuss history, epidemiology, etiology, pathophysiology, classification of epilepsy, symtomps, diagnosis, management of epilepsy and its future trends.
%K Anti-epileptic drugs
%K pathophysiology
%K seizures
%K epidemiology
%K hypersynchrony
%U http://www.pharmascitech.in/admin/php/uploads/36_pdf.pdf