%0 Journal Article
%T A Randomized Controlled Trial of Intravenous Remifentanil Compared with Intramuscular Meperidine for Pain Relief in Labor
%A A. Shahriari
%A M. Khooshideh
%J Journal of Medical Sciences
%D 2007
%I 
%X The aim of this study is to compare the analgesic efficacy and safety of Remifentanil and Meperidineduring an uncomplicated labor, Forty full term parturient with singleton pregnancy and vertex presentation were randomized to receive either Remifentanil (25-50 ¦Ìg every 4 min, IV) or Meperidine (1 mg kg-1, IM) during active labor and delivery. A Visual Analog Scale (VAS) was used to assess the severity of pain. Also maternal side effects (nausea and vomiting), sedation, perinatal outcome, maternal satisfaction and duration of labor were assessed. The pain scores were lower in Remifentanil group at 60 min after analgesia (p<0.0001) and during the first stage of labor (p<0.0001) than Meperidine group. The pain scores in second stage of labor were also lower in Remifentanil group (p = 0/013). Ninty five percent of women rated analgesia as good to excellent in Remifentanil group as compared with 35% in meperidine group (p<0.0001). Side effects such as sedation, nausea and vomiting and respiratory depression and hemoglobin oxygen desaturation were uncommon .Also no significant differences were seen between groups from mode of delivery or neonatal outcomes. Conclusion: Remifentanil with a bolus dose of 25-50 ¦Ìg offers a good level of maternal satisfaction with a minimal effect on the neonate, butadequate continuous monitoring is necessary for avoiding maternal side effects.
%K labor
%K analgesia
%K Meperidine
%K Remifentanil
%K delivery
%U http://docsdrive.com/pdfs/ansinet/jms/2007/635-639.pdf