%0 Journal Article
%T Clinical Analysis of Influenza A (H1N1) Viral Pneumonia Complicated with Bacterial Infection
%A Xixin Yan
%A Haibo Xu
%A Fangfang Qu
%A Yue Liu
%A Xiumin Zhang
%J Chinese Medicine
%P 15-18
%@ 2151-1926
%D 2013
%I Scientific Research Publishing
%R 10.4236/cm.2013.41003
%X <p align=\"justify\">
	<b><span style=\"font-family:Verdana;\">Purpose</span></b><b><span style=\"font-family:Verdana;\">:</span></b><span style=\"font-family:Verdana;\"> We investigated the efficacy of potent or combined antibiotics in patients suffering bacterial infections sec</span><span style=\"font-family:Verdana;\">ondary to H1N1 by retrospectively analyzing their bacterial pathogen spectrum and clinical characteristics.</span><span> </span><b><span style=\"font-family:Verdana;\">Methods</span></b><b><span style=\"font-family:Verdana;\">:</span></b><span style=\"font-family:Verdana;\"> Multi-center retrospective analysis was performed using clinical data of H1N1 patients from 27 hospitals in Hebei Province, China, from November 1 to December 31, 2009.</span><span> </span><b><span style=\"font-family:Verdana;\">Results</span></b><b><span style=\"font-family:Verdana;\">:</span></b><span style=\"font-family:Verdana;\"> Of 480 H1N1-infected patients enrolled from an inpatient clinic, 91 were positive for bacterial culture. Bacteria were detected in sputum culture at 7.00</span><span> </span><span style=\"font-family:Verdana;\">¡À</span><span> </span><span><span style=\"font-family:Verdana;\">8.87 days post-admission. Compared with the negative group, the patients in the positive sputum culture group had a higher mean age and prevalence of basic diseases, higher APECHEII (Acute Physiology and Chronic Health Evaluation II) score within 24 hours of admission, longer hospital stays, and higher mortality. In total, 189 bacterial strains were isolated, with the majority of samples testing positive for </span><i><span style=\"font-family:Verdana;\">Acinetobacter baumanii</span></i><span style=\"font-family:Verdana;\"> (47), </span><i><span style=\"font-family:Verdana;\">Streptococcus viridians</span></i><span style=\"font-family:Verdana;\"> (26), or </span><i><span style=\"font-family:Verdana;\">Pseu</span></i></span><i><span style=\"font-family:Verdana;\">domonas aeruginosa</span></i><span><span style=\"font-family:Verdana;\"> (19). </span><i><span style=\"font-family:Verdana;\">S. viridians</span></i><span style=\"font-family:Verdana;\"> was the major cause of infection within 3 days of admission, while </span><i><span style=\"font-family:Verdana;\">A. baumanii</span></i><span style=\"font-family:Verdana;\"> infection was more prevalent from 4 days post-admission; there was a significant difference in the constituent ratio be</span></span><span style=\"font-family:Verdana;\">tween the two pathogens (p</span><span> </span><span
%K Influenza A H1N1
%K Bacteria
%K Antibiotics
%K Mortality
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=28562