%0 Journal Article
%T Clinical Manifestations and MR Imaging Features In Hypothalamic Hamartomas
%A £¿zlem ALKAN
%A Osman KIZILKILI£¿
%A Tuba KARSANTI£¿Z¨¹
%A T¨¹lin YILDIRIM
%J Journal of Neurological Sciences
%D 2009
%I Ege University Press
%X Hypothalamic hamartomas (HH) are rare non-neoplastic congenital malformations. The aims of this study are to demonstrate the brain MR findings and clinical manifestations in children with HH and the literature is reviewed. We have evaluated 6 children with HH diagnosed by brain MR imaging. We analyzed age at seizure onset, seizure types, neuropsychological assessment, and the presence of precocious puberty, electroencephalogram and MR findings. Among 6 HH patients, 2 manifested precocious puberty, 2 had experienced seizures, and 1 presented with both precocious puberty and seizures, and 1 presented with hyperactivity. MR imaging showed hypothalamic mass that was isointense to brain parenchyma on T1- weighted images and isointense-or hyperintense on T2-weighted images, without contrast enhancement. The size of the lesions does not change in the course of follow-up. Typical clinical presentation, peculiar location and MR imaging features strongly favour the HH diagnosis. Accurate diagnosis and classification is important for the selection of treatment modality.
%K Hypothalamic hamartoma
%K MR imaging
%K gelastic seizure
%K precocious puberty
%U http://www.jns.dergisi.org/pdf.php3?id=296