%0 Journal Article
%T Modulation of peroxisomes abundance by argan oil and lipopolysaccharides in acyl-CoA oxidase 1-deficient fibroblasts
%A Riad El Kebbaj
%A Soufiane El Kamouni
%A Hammam I. El Hajj
%A Pierre Andreoletti
%A Joseph Gresti
%A Norbert Latruffe
%A M¡¯Hammed Sa£¿d El Kebbaj
%A Joseph Vamecq
%A G¨¦rard Lizard
%A Boubker Nasser
%A Mustapha Cherkaoui-Malki
%J Health
%P 62-69
%@ 1949-5005
%D 2013
%I Scientific Research Publishing
%R 10.4236/health.2013.51009
%X <p align=\"justify\">
	<span style=\"font-family:'Arial','sans-serif';font-size:10pt;\">Pseudo-neonatal adrenoleukodystrophy</span><span style=\"font-family:'Arial','sans-serif';font-size:10pt;\"> (P-NALD) is a neurodegenerative disorder caused by acyl-CoA oxidase 1 (ACOX1) deficiency with subsequent impairment of peroxisomal fatty acid <i>¦Â</i>-oxidation, accumulation of very long chain fatty acids (VLCFAs) and strong reduction in perox<span>isome abundance. Increase in peroxisome</span> number has been previously suggested to improve peroxisomal disorders, and in this perspective, <span>the present work was aimed at exploring</span> whether modulation of peroxisomes abundance could be <span>achieved in P-NALD fibroblasts. Here we</span> showed that treatment with the natural Argan oil induced peroxisome proliferation in P-NALD fibroblasts. This induction was independent on activations of both nuclear receptor PPAR<i>¦Á</i> and its coacti<span>vator PGC-1<i>¦Á</i>. Lipopolysaccharides (LPS)</span> treatment, which caused inflammation, induced also a peroxisome proliferation that, in contrast, was dependent on activations of PPAR</span><i><span style=\"font-family:'Arial','sans-serif';font-size:10pt;\">¦Á </span></i><span style=\"font-family:'Arial','sans-serif';font-size:10pt;\">and PGC-1<i>¦Á</i>. By its ability to induce peroxisome proliferation, Argan oil is suggested to be of potential therapeutic use in patients with P-NALD.</span> 
</p>
%K Acyl-CoA Oxidase 1
%K Argan Oil
%K LPS
%K PGC-1a
%K Peroxisome Proliferation
%K P-NALD
%K PPARa
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=26522