%0 Journal Article
%T A model System for Validation of PET  Radiopharmaceuticals: Focusing on Tumor  Microenvironment
%A Xiao-Feng Li
%A Huijie Jiang
%A Yuanyuan Ma
%A Tao Huang
%A Xindao Yin
%A A. Cahid Civelek
%A Baozhong Shen
%J International Journal of Medical Physics,Clinical Engineering and Radiation Oncology
%P 19-29
%@ 2168-5444
%D 2013
%I Scientific Research Publishing
%R 10.4236/ijmpcero.2013.21004
%X <p class=\"MsoNormal\" style=\"text-align:justify;\">
	<span lang=\"EN-US\">Positron emission tomography (PET) imaging has emerged
as an important clinical tool for cancer management, and specifically targeted
radiopharmaceuticals play critical roles on PET molecular imaging. Solid
cancers have highly complex and heterogeneous microenvironment, this review
focused on those microenvironmental factors such as hy</span><span lang=\"EN-US\">poxia,
proliferation and perfusion and, accordingly, a novel test system for
validation of current and novel targeted im</span><span lang=\"EN-US\">aging
radiopharmaceuticals. In this review, we have introduced the establishment of
cancer and metastases models in nude mice, visualization of microenvironmental
components of hypoxia, proliferation, perfusion, stroma and necrosis in cancers
and metastases for establishing the microenvironment based model system, and
validation of several radio</span><span lang=\"EN-US\">- </span><span lang=\"EN-US\"><span>pharmaceuticals such as </span><st1:chmetcnv tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"18\" unitname=\"F\" w:st=\"on\"><sup><span>18</span></sup><span>F</span></st1:chmetcnv><span>-fluoro-2-deoxyglucose (</span><st1:chmetcnv tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"18\" unitname=\"F\" w:st=\"on\"><sup><span>18</span></sup><span>F</span></st1:chmetcnv><span>-FDG) </span><st1:chmetcnv tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"18\" unitname=\"F\" w:st=\"on\"><sup><span>18</span></sup><span>F</span></st1:chmetcnv><span>-fluorothymidine (</span><st1:chmetcnv tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"18\" unitname=\"F\" w:st=\"on\"><sup><span>18</span></sup><span>F</span></st1:chmetcnv><span>-FLT), </span><st1:chmetcnv tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"18\" unitname=\"F\" w:st=\"on\"><sup><span>18</span></sup><span>F</span></st1:chmetcnv><span>-misonidazole (</span><st1:chmetcnv tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"18\" unitname=\"F\" w:st=\"on\"><sup><span>18</span></sup><span>F</span></st1:chmetcnv><span>-</span></span><span lang=\"EN-US\"> </span><span lang=\"EN-US\"><span>FMISO) using the
system. We found that </span><st1:chmetcnv tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"18\" unitname=\"F\" w:st=\"on\"><sup><span>18</span></sup><span>F</span></st1:chmetcnv><span>-FLT
accumulates in proliferating
%K &lt
%K sup&gt
%K 18&lt
%K /sup&gt
%K F-Fluoro-2-Deoxyglucose
%K &lt
%K sup&gt
%K 18&lt
%K /sup&gt
%K F-Fluorothymidine
%K &lt
%K sup&gt
%K 18&lt
%K /sup&gt
%K F-Misonidazole
%K Microenvironment
%K Hypoxia
%K Proliferation
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=28049