%0 Journal Article %T Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia %A Masoud Soheili %A Mostafa Rezaei Tavirani %A Mahmoud Salami %J Neuroscience & Medicine %P 362-367 %@ 2158-2947 %D 2012 %I Scientific Research Publishing %R 10.4236/nm.2012.34044 %X An important marker in neurodegenerative Alzheimer”Æs disease (AD) is abnormal production of amyloid beta (A¦Ā) peptide leading to formation of plaques in the brain. Through decreasing A¦Ā aggregates, anti-inflammatory agents, phagocytosis, and proteolytic enzymes are known to decline risk of A¦Ā plaque formation. In the previous study we showed that aqueous extract of Lavandula angustifolia (lavender), with known anti-inflammatory effects, improves memory deficits in animal model of Alzheimer. Here, we assess if lavender play a role in clearance of A¦Ā plaques in the hippocampus. The Alzheimeric animals were created with intracerebroventricular injection of A¦Ā 1-42. To confirm formation of A¦Ā plaques, brain sections were stained by Congo red method. Twenty days post-injection they were administered with different doses (50, 100 and 200 mg/kg) of the aqueous extract of lavender for duration of 20 days. Our results demonstrated that 50 mg/kg of lavender not effectively influenced the A¦Ā plaques. On the other hand, the herbal medicine at the doses of 100 and 200 mg/kg markedly decreased the extent of A¦Ā aggregates. We concluded that the lavender extract dose dependently underlies elimination of A¦Ā plaques. The exact mechanism by which the herbal medicine removes the A¦Ā aggregates needs to be elucidated. %K Alzheimer %K Amyloid Beta %K Lavandula angustifolia %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=26193