%0 Journal Article
%T A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation
%A Henningsen Kristoffer M A
%A Olesen Morten S
%A Sajadieh Golnaz
%A Haunsoe Stig
%J Journal of Negative Results in BioMedicine
%D 2013
%I BioMed Central
%R 10.1186/1477-5751-12-1
%X Background Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF. Findings We included 178 young patients with lone AF and the first episode before the age of 40 years, and a control group of 875 healthy individuals. We analyzed a promoter SNP ( 131CG) (rs4950928) in the Chitinase 3¨Clike 1 (CHI3L1) gene encoding YKL-40, which had previously been associated with elevated levels of YKL-40. Conclusions The ( 131CG) genotype was not associated with increased risk of AF. Genetically increased YKL-40 levels were not associated to AF.
%K YKL-40
%K Single nucleotide polymorphism
%K Inflammation
%K Atrial fibrillation
%U http://www.jnrbm.com/content/12/1/1