%0 Journal Article
%T BDNF Gene Polymorphism in Patients With Temporal Lobe Epilepsy
%A G¨¹lcan SARGIN
%A Candan G¨¹RSES
%A Naci £¿£¿NE
%A Nerses BEBEK
%J Journal of Neurological Sciences
%D 2008
%I Ege University Press
%X Objective: Brain-derived neurotrophic factor (BDNF), a neurotrophin which performs its activity through neurotrophic tyrosine kinase receptors, is one of the candidate genes for epilepsy. Our aim is to investigate brain-derived neurotrophic factor (BDNF) gene polymorphisms as an candidate gene in patients with temporal lobe epilepsy.Methods: One hundred and seven patients included in the study were divided into two groups as mesial temporal sclerosis (MTS) (n:62) and non-MTS (n:45), and compared with 104 healthy controls.C-T substitution at position 240 in the BDNF gene which corresponds to the 270C/T polymorphism was analysed using a PCR-restriction fragment length polymorphism (RFLP) method.Results: From a clinical point of view, the history of febrile convulsions and status epilepticus in medically intractable patients with MTS was statistically very significant in comparison to the other group (p<0.000), as expected.There was no statistical significance in the distribution of genotypes between the TLE group (MTS group and non-MTS group) and the control group individuals.Conclusion: Hence, in patients with temporal lobe epilepsy, BDNF gene polymorphism was not detected. The indication of lack of correlation between BDNF gene polymorphism and TLE contributes to literature in that it makes it possible for future researchers to compare and contrast their results with studies that had not yielded statistically significant results.
%K Brain-derived neurotrophic factor (BDNF)
%K temporal lobe epilepsy
%K mesial temporal sclerosis
%K polymorphism
%K gene
%U http://jns.dergisi.org/pdf.php3?id=236