%0 Journal Article
%T Challenges on Induction of Broadly Neutralizing Antibodies for Optimization of HIV Vaccines Development and Vectored Immunoprophylaxis
%A Pankaj Kumar
%J Journal of Immune Based Therapies, Vaccines and Antimicrobials
%P 9-13
%@ 2168-1554
%D 2013
%I Scientific Research Publishing
%R 10.4236/jibtva.2013.21002
%X <p align=\"justify\">
	<span>Despite extensive research efforts, a preventive </span><span>human immunodeficiency virus</span><span> (HIV) vaccine remains one of the major challenges in the field of AIDS research. Experimental strategies which have been proven successful for other viral vaccines are not enough to tackle HIV-1 and new approaches to design effective preventive AIDS vaccines are of utmost importance. Due to enormous diversity among global circulating HIV strains, an effective HIV vaccine must </span><span>elicit broadly protective antibodies based responses; therefore discovering new broadly neutralizing antibodies (</span><span>bNAbs)</span><span> against HIV has become major focus in HIV vaccine research. However f</span><span>urther understanding of the</span><span> viral targets of such antibodies and </span><span>mechanisms of action of bNAbs is required </span><span>for advancement of HIV vaccine research.</span><span> This technical note discusses our current knowledge on the</span><span> bNAbs and </span><span>immunoprophylaxis using viral vectors </span><span>with </span><span>their relevance in designing of new candidates to HIV-1 vaccines.</span><span></span> 
</p>
%K HIV
%K AIDS
%K Broadly Neutralizing Antibodies (bNAbs)
%K Vectored Immunoprophylaxis
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=27117