%0 Journal Article
%T Pancreatite autoimune e diagn車stico diferencial com a neoplasia do pancreas: A prop車sito de um caso cl赤nico Autoimmune pancreatitis and differential diagnosis with neoplasm of the pancreas: Based on a clinical case
%A Juliana Oliveira
%A Gorete Jorge
%A Ant車nio Milheiro
%A Francisco Castro Sousa
%J Jornal Portugu那s de Gastrenterologia
%D 2012
%I Sociedade Portuguesa de Gastrenterologia
%X A Pancreatite Auto-imune (PAI) 谷 um tipo de pancreatite cr車nica caracterizada, histol車gicamente, por um infiltrado linfoplasmocit芍rio e fibrose periductal. O quadro cl赤nico pode mimetizar um carcinoma da cabe a do pancreas, principalmente nos casos de doen a cef芍lica, sendo caracterizado por icter赤cia obstructiva, dor abdominal e perda ponderal. Esta entidade cl赤nica pode estar associada a outras doen as auto-imunes e o diagn車stico tem por base os crit谷rios diagn車sticos sugeridos pela Cl赤nica Mayo e pela Sociedade Japonesa do Pancreas, em que associam as caracter赤sticas histol車gicas e radiol車gicas 角 eleva  o da IgG4 e 角 resposta ao tratamento com cortic車ides. Apresentamos um caso cl赤nico de uma doente submetida a Duodenopancreatectomia cef芍lica, devido a um diagn車stico pr谷-operat車rio (cl赤nico e radiol車gico) de carcinoma da cabe a do pancreas. O estudo anatomo-patol車gico revelou tratar-se de uma pancreatite linfoplasmocit芍ria e o estudo imunol車gico posterior corroborou o diagn車stico de Pancreatite Auto Imune. Este artigo tem como objectivo alertar para o diagn車stico diferencial com o carcinoma da cabe a do pancreas; de modo a evitar a realiza  o de uma interven  o com taxas de morbilidade e mortalidade relevantes numa entidade nosol車gica sens赤vel 角 terap那utica com cortic車ides The Autoimmune pancreatitis (AIP) is a type of chronic pancreatitis characterized histologically by a lymphoplasmocytic infiltration and periductal fibrosis. The clinical presentation may mimic a carcinoma of the head of the pancreas, especially in cases of cephalic disease, characterized by obstructive jaundice, abdominal pain and weight loss. This clinical entity may be associated with other autoimmune diseases and the diagnosis is based on the diagnostic criteria suggested by Mayo Clinic and the Japanese Society of the Pancreas, which associate the histological and radiological features to the increase in IgG4 and response to treatment with corticosteroids. We present a case report of a patient who underwent a cephalic pancreatoduodenectomy, due to a preoperative diagnosis (clinical and radiological) of carcinoma of the head of the pancreas. The pathological study revealed that it was a lymphoplasmocytic pancreatitis and immunological study later confirmed the diagnosis of Auto Immune Pancreatitis. This article aims to raise awareness for the differential diagnosis with carcinoma of the head of the pancreas, to avoid performing a surgery with relevant morbidity and mortality rates in a disease sensitive to treatment with corticosteroids
%K Pancreatite autoimune
%K carcinoma da cabe a do pancreas
%K icter赤cia obstructiva
%K infiltrado linfoplasmocit芍rio
%K IgG4
%K duodenopancreatectomia cef芍lica
%K Autoimmune pancreatitis
%K carcinoma of the head of the pancreas
%K obstructive jaundice
%K lymphoplasmocytic infiltration
%K IgG4
%K cephalic pancreatoduodenectomy
%U http://www.scielo.oces.mctes.pt/scielo.php?script=sci_arttext&pid=S0872-81782012000100009