%0 Journal Article
%T Fatores de Virul那ncia de Bacillus thuringiensis Berlinier: O Que Existe Al谷m das Prote赤nas Cry?
%A Gislayne Trindade Vilas-Bˋas
%A Rita C. Alvarez
%A Clelton A. dos Santos
%A Laurival A. Vilas-Boas
%J EntomoBrasilis
%D 2012
%I Vassouras, RJ
%X As prote赤nas Cry produzidas pela bact谷ria entomopatog那nica Bacillus thuringiensis Berliner s o bem conhecidas devido a alta citotoxicidade que exibem a uma variedade de insetos-alvo. O modo de a  o destas prote赤nas 谷 espec赤fico e torna os produtos 角 base de B. thuringiensis os mais amplamente utilizados em programas de controle biol車gico de pragas na agricultura e de importantes vetores de doen as humanas. Contudo, embora as prote赤nas Cry sejam os fatores de virul那ncia inseto-espec赤fico mais conhecidos, linhagens de B. thuringiensis apresentam tamb谷m uma ampla gama de fatores de virul那ncia, os quais permitem 角 bact谷ria atingir a hemolinfa e colonizar eficientemente o inseto hospedeiro. Dentre estes fatores, destacam-se as prote赤nas Vip, Cyt, enterotoxinas, hemolisinas, fosfolipases, proteases, enzimas de degrada  o, al谷m das recentemente descritas parasporinas. Essa revis o aborda a a  o desses fatores de virul那ncia, bem como a caracteriza  o e o controle da express o de seus genes. Adicionalmente, s o discutidos aspectos relacionados ao nicho ecol車gico da bact谷ria com 那nfase nas caracter赤sticas envolvidas com a biosseguran a da utiliza  o dos produtos 角 base de B. thuringiensis para o controle biol車gico de insetos-alvo.Virulence Factors of Bacillus thuringiensis Berliner: Something Beyond of Cry Proteins?Abstract. The Cry proteins produced by the entomopathogenic bacterium Bacillus thuringiensis Berliner are widely known due to its high toxicity against a variety of insects. The mode of action of these proteins is specific and becomes B. thuringiensis-based products the most used in biological control programs of insect pests in agriculture and of important human disease vectors. However, while the Cry proteins are the best-known insect-specific virulence factor, strains of B. thuringiensis show also a wide range of other virulence factors, which allow the bacteria to achieve the hemolymph and colonize efficiently the insect host. Among these factors, we highlight the Vip proteins, Cyt, enterotoxins, hemolysins, phospholipases, proteases and enzymes of degradation, in addition to the recently described parasporin. This review explores the action of these virulence factors, as well as, the characterization and control of expression of their genes. Additionally, we discuss aspects related to the ecological niche of the bacteria with emphasis on the characteristics involved in the biosafety of the use of B. thuringiensis-based products for biological control of target insects.
%K Biological control
%K Biosafety
%K Virulence factors
%K Controle Biol車gico
%K Fatores de virul那ncia
%K Biosseguran a
%U http://www.periodico.ebras.bio.br/ojs/index.php/ebras/article/view/146/159