%0 Journal Article
%T Uso do infliximab na consulta de gastrenterologia pedi芍trica The use of infliximab in a pediatric gastroenterology consultation
%A Rita Marques
%A Filipa Caldeira
%A Cl芍udia Costa
%A Jos谷 da Cunha
%J Jornal Portugu那s de Gastrenterologia
%D 2012
%I Sociedade Portuguesa de Gastrenterologia
%X Introdu  o: O infliximab e um anticorpo monoclonal utilizado na doen a inflamat車ria intestinal (DII) refrataria. Objetivo: Avaliar a resposta clinica e os efeitos adversos da terap那utica com infliximab na DII em doentes pedi芍tricos. M谷todos: Estudo descritivo, anal赤tico e transversal dos doentes da consulta de gastrenterologia pedi芍trica que ingressaram em protocolo terap那utico com infliximab. Resultados: Dos 6 doentes que realizam terap那utica monoclonal com infliximab, 5 apresentam doen a de Crohn moderada a grave e um colite ulcerosa. Verificou-se remiss o clinica em 5 doentes. Observou-se resolu  o das altera  es anal赤ticas apos 6 meses de terap那utica. Verificaram-se 2 rea  es al谷rgicas ligeiras e uma eleva  o transit車ria das transaminases. Conclus es: Em concordancia com o descrito na literatura, na nossa popula  o a terapeutica com infliximab tem sido bem tolerada e eficaz no controlo da doen a. Introduction: Infliximab is a monoclonal antibody used in refractory inflammatory bowel disease (IBD). Aim: To evaluate the clinical response and adverse effects of infliximab therapy in paediatric IBD patients. Methods: Analytic, descriptive and cross sectional study of Outpatient Clinic of Pediatric Gastroenterology treated with infliximab. Results: Of six patients treated with infliximab, five have moderate to severe Crohn＊s disease and one present Ulcerative Colitis. There was clinical remission in five patients. Resolution in analytical changes was observed after 6 months of therapy. There were two mild allergic reactions and a transient elevation of transaminases. Conclusions: In accordance with the literature, in our population, infliximab therapy has been well tolerated and effective in disease control.
%K Infliximab
%K Doen a inflamat車ria intestinal
%K Pediatria
%K Infliximab
%K Inflammatory bowel disease
%K Pediatric
%U http://www.scielo.oces.mctes.pt/scielo.php?script=sci_arttext&pid=S0872-81782012000300004