%0 Journal Article
%T Evaluation of serum level of IL-12 in patients with
%A Mohammad Kazemi Arababadi1
%A Ali Akbar Pourfathollah2
%A Gholamhossein Hassanshahi1
%A Vahid Pooladvand3
%J Journal of Mazandaran University of Medical Sciences
%D 2009
%I Mazandaran University of Medical Sciences
%X (Received 26 August, 2009 ; Accepted 18 Novamber, 2009)AbstractBackground and purpose: Occult hepatitis B infection (OBI) is a form of hepatitis in which despite the absence of detectable HBsAg, HBV-DNA is present in peripheral blood of patients. Investigators believed that the genetics and immunological parameters may be different in resistant individuals and patients. Cytokines, such as IL-12, could be leading to alteration in viral immune response. The main aim of this study was to investigate the serum level of IL12 in OBI patients.Materials and methods: In this study, the plasma samples of 3700 HBsAg negative blood donors were tested for anti-HBs by ELISA. The HBsAg negative and anti-HBc positive samples were selected and screened for HBV-DNA by PCR. HBV-DNA positive samples were assigned as OBI cases and ELISA technique were performed to examine the serum level of IL-12 in OBI and 100 healthy controls.Results: Our results showed that there was no significant difference in serum level of IL-12 between OBI patients and controls.Conclusion: In order to be clear of viruses, L-12 is increased in viral infection. Based on the results of this study, it is concluded that OBI patients can not produce enough IL-12 to clear HBV. J Mazand Univ Med Sci 2009; 19(72): 81-83 (Persian)
%K Occult hepatitis B infection
%K IL-12
%K HBsAg
%K HBV-DNA
%U http://www.mazums.ac.ir/index.php?digital_library&do=downloadPdf&sid=834