%0 Journal Article
%T Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report
%A Vikas Mehta
%A Chad Ellimottil
%A Jodi Speiser
%A Milind Velankar
%J Journal of Interdisciplinary Histopathology
%D 2013
%I GESDAV
%R 10.5455/jihp.20130121075815
%X B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements, also known as ˇ°double hitˇ± lymphomas (DHL), are rare neoplasms characterized by highly aggressive clinical behavior, complex karyotypes, and a spectrum of pathological features overlapping with Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). Primary renal lymphoma (PRL) by definition is a renal lymphoma without evidence of systemic involvement. PRL is extremely rare with less than 100 cases of both Hodgkin disease and non-Hodgkin lymphoma reported in literature. Double hit lymphomas have extremely poor prognosis, and high resistance to intensive chemotherapy, including high-dose chemotherapy. We describe a very rare case of DHL arising in kidney as PRL in whom concurrent IGH-BCL2 and MYC rearrangements were detected. [J Interdiscipl Histopathol 2013; 1(2.000): 93-97]
%K Primary renal lymphoma
%K double hit lymphoma
%U http://www.scopemed.org/fulltextpdf.php?mno=31474