%0 Journal Article
%T Inhibitory Effect of Nano-HA Particles on Human U87 Glioblastoma Cells Viability
%A TIAN Ang
%A WANG Chao
%A XUE Xiang-Xin
%A WU Anhua
%A GUAN Ge-Fei
%A WANG Li
%A QIU Bo
%J 无机材料学报
%D 2010
%I Science Press
%R 10.3724/sp.j.1077.2009.09246
%X To evaluate the effects of Hydroxyapatite nano-particles (nano-HA) with different morphologies on human U87 glioblastoma cell line (U87), three kinds of nano-HA were designed and synthesized, and a co-culture system containing nano-HA and U87 cells was established. Polyethylene glycol (PEG) was also added to the HA medium system for the samples stabilization. After determining the stabilization and high dispersed nanometer size of nano-HA in the medium system using Transmission electron microscope (TEM) and dynamic light scattering (DLS), the effects of nano-HA on GBM cells were assessed with an MTT method. Results showed that nano-HA could effectively inhibit U87 cells proliferation. Compared with other nano-HA, the needle-like nano-HA were more powerful in inhibiting U87 cells proliferation. Toll-like receptor 4 (TLR4) induced by different nano-HA may be one reason for their different bioactivity, however, the correlation between nano-HA and TLR4 expression needs further investigation.
%K hydroxyapatite
%K glioblastoma
%K toll-like receptor 4
%K polyethylene glycol.
%U http://www.jim.org.cn/fileup/PDF/20100121.pdf