%0 Journal Article
%T NEW SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF GATIFLOXACIN IN TABLETS USING N, N- DI METHYL UREA AS HYDROTROPIC AGENT
%A prabhat kumar jain
%A Abhilasha Thakur
%A Anurekha Jain
%A Anuj Modi
%J Journal of Global Pharma Technology
%D 2010
%I 
%R 10.1234/jgpt.v2i3.100
%X A novel, safe and sensitive method of spectrophotometric estimation in ultraviolet region has been developed using 7.5 M N, N- di methyl urea solution as hydrotropic agent for the quantitative determination of Gatifloxacin, a poorly water-soluble drug in tablet dosage form. Gatifloxacin shows maximum absorbance at 333 nm. Beer's law was obeyed in the concentration range of 10 to 60 ¦Ìg/ml, N N- di methyl urea does not absorb above 260 nm. Commonly used tablet excipients and N, N- di methyl urea did not interfere in spectrophotometric estimation. Results of the analysis were validated statistically and by recovery studies. Using 7.5 M N, N- di methyl urea solution for analysis of two different tablet formulations of Gatifloxacin , the percent label claims and percent recoveries estimated were close to 100 with low values of standard deviation, percent coefficient of variation and standard error.
%K Gatifloxacin
%K hydrotropy
%K N
%K N- di methyl urea
%K spectrophotometry
%U http://jgpt.co.in/jgpt/index.php/jgptjournal/article/view/100