%0 Journal Article
%T Perianal Paget¡¯s Disease and Malignancies of Lower Hindgut and Anal Canal
%A Gianluca Pellino
%A Guido Sciaudone
%A Silvestro Canonico
%A Francesco Selvaggi
%J Journal of Gastroenterology and Hepatology Research
%D 2012
%I Thomson Research Publishing Group
%R 10.6051/j.issn.2224-3992.2012.01.038
%X Perianal Paget¡¯s disease (PPD) consists of a skin neoplasia whichcan be either primary or secondary to an underlying internal malignancy.Treatment of perianal Paget¡¯s disease associated with primarycolonic or anal adenocarcinoma is secondary to the treatment of theprimary tumor and, thus, accurate clinical, pathological and immunohistochemicalassessment is essential. Adenocarcinomas are estimatedto be only 10% of anal cancer, and anal mucinous or colloidadenocarcinoma is an even rarer entity. We reviewed literature concerningthe association between malignancies of the lower gastrointestinaltract and anal canal not associated with a chronic fistula-inanoand perianal Paget¡¯s disease, focusing on immunohystochemicaldifferential diagnosis and management. Immunohistochemistryis very useful in choosing the ideal treatment for perianal Paget¡¯s disease; our ¡°immunopanel¡± is useful to classify perianal Paget¡¯sdisease.
%K Perianal Paget¡¯s disease
%K Anal mucinous adenocarcinoma
%K Immunopanel
%K Pagetoid spread
%K Cytokeratine
%K PPD
%U http://www.ghrnet.org/index.php/joghr/article/view/29