%0 Journal Article %T Perianal Paget¡¯s Disease and Malignancies of Lower Hindgut and Anal Canal %A Gianluca Pellino %A Guido Sciaudone %A Silvestro Canonico %A Francesco Selvaggi %J Journal of Gastroenterology and Hepatology Research %D 2012 %I Thomson Research Publishing Group %R 10.6051/j.issn.2224-3992.2012.01.038 %X Perianal Paget¡¯s disease (PPD) consists of a skin neoplasia whichcan be either primary or secondary to an underlying internal malignancy.Treatment of perianal Paget¡¯s disease associated with primarycolonic or anal adenocarcinoma is secondary to the treatment of theprimary tumor and, thus, accurate clinical, pathological and immunohistochemicalassessment is essential. Adenocarcinomas are estimatedto be only 10% of anal cancer, and anal mucinous or colloidadenocarcinoma is an even rarer entity. We reviewed literature concerningthe association between malignancies of the lower gastrointestinaltract and anal canal not associated with a chronic fistula-inanoand perianal Paget¡¯s disease, focusing on immunohystochemicaldifferential diagnosis and management. Immunohistochemistryis very useful in choosing the ideal treatment for perianal Paget¡¯s disease; our ¡°immunopanel¡± is useful to classify perianal Paget¡¯sdisease. %K Perianal Paget¡¯s disease %K Anal mucinous adenocarcinoma %K Immunopanel %K Pagetoid spread %K Cytokeratine %K PPD %U http://www.ghrnet.org/index.php/joghr/article/view/29