%0 Journal Article
%T Calcineurin signalling mechanisms in myocardial hypertrophy
%A Jian-Chun Wang
%A Yong Zhao
%A Jian-Hua Shao
%J 老年心脏病学杂志(英文版)
%D 2010
%I Science Press
%X Calcineurin dephosphorylates multiple serine residues near the N terminus of NFAT proteins enabling them to translocate from cytoplasm to nucleus, where they activate a subset of hypertrophic response genes. Transgenic mice over-expressing a constitutively active form of calcineurin or NFAT3, developed obviously hypertrophy and heart failure or sudden death proving its pathogenic role. Here we used literatures on MEDLINE (2000-2011), systematically reviewed the new development of calcineurin signaling pathway in myocardial hypertrophy.
%K Calcineurin
%K signal transduction
%K hypertrophy
%U http://www.jgc301.com/ch/reader/create_pdf.aspx?file_no=2011012013&year_id=2010&quarter_id=4&falg=1