%0 Journal Article
%T Reversible switch from hemoglobin A to C in sheep and recovery from anemia following experimental infection with Anaplasma ovis
%A Ingrid Alloggio
%A Giuseppe De Ruvo
%A Alessandra Torina
%A Anna Caroli
%J Italian Journal of Animal Science
%D 2010
%I PAGEPress Publications
%R 10.4081/ijas.2009.s2.27
%X Anemia causes a change in the type of circulating hemoglobin (Hb) in sheep carrying the ¦ÂA-globin haplotype, where the Hb A is replaced with Hb C, unlike Hb B. The effect of the substitution of Hb A with Hb C on the recovery from anemia was investigated by comparing the hematological picture of sheep, following experimental infection with Anaplasma ovis. The blood values were obtained from 3 AB and 3 BB Hb sheep after the development of the disease where anemia is a pathognomonic symptom. The expression of the silent gene encoding for Hb C was detected by isoelectric focusing and quantified by high performance liquid chromatography. Both Hb AB genotype and Hb C occurrence were involved in the lower recovery from anemia in the trial.
%K Hb polymorphism
%K Silent gene expression
%K Response to anemia
%K Sheep anaplasmosis.
%U http://www.aspajournal.it/index.php/ijas/article/view/273