%0 Journal Article
%T COMPARATIVE EFFECT BETWEEN CHITOSAN AND CHITOSAN-Cu COMPLEX ON CARBON-TETRACHLORIDE (CCL4) INDUCED LIVER DAMAGE IN RATS
%A El-Habibi
%A E.M.
%A Sirag
%A H.M. and Edrees
%A G.M.
%J The Egyptian Journal Of Hospital Medicine
%D 2009
%I Pan Arab League of Continuous Medical Education
%X BACKGROUND: Carbon tetrachloride (CCl4 ) is a toxic material known to induce lipid peroxidation and liver damage. The possible protective roles that involved by chitosan or chitosan-Cu complex against CCl4 induced liver intoxication were investigated in male rats. RESULTS: CCl4 administred at dose 20 mg/kg body weight i.p., exceed malondialdehyde (MDA) and protein carbonyle (PC), depleted superoxide dismutase (SOD) and glutathione (GSH), in concomitant with marked increase in investigated liver function parameters , alanine aminotransferase and aspartate aminotransferase (ALT, AST), impaired serum and liver total protein , albumin and globulin. An elevation in serum and hepatic total lipids, total cholesterol, triglycerides and serum LDL and VLDL levels as well as a low level of HDL were recorded. In the same time, there was a significant increase in sodium and iron contents in the serum while a significant decrease in potassium and zinc contents were recorded. Animals pretreated with chitosan (200 mg /kg body weight) orally by stomach tube for 21 consecutive days prior to CCl4 challenge significantly attenuated most of the tested parameters, strengthen antioxidant defense system, ameliorated liver function effectively. Chitosan-Cu complex has a protective effect by a higher degree than that of chitosan only. CONCLUSION: These findings suggest that pretreatment with chitosan-Cu complex has higher hepato-protective effects than that of only chitosan against CCl4 induced toxicity in rat.
%K Carbon tetrachloride (CCl4) - Chitosan - lipid peroxidation - liver functions
%U http://egyptianjournal.net78.net/36_2.pdf